Abstract

Objective To evaluate the therapeutic effect of endoscopic full-thickness resection (EFTR) for gastric stromal tumors. Methods A total of 33 patients with gastric stromal tumor origination from deep muscularis propria layer received EFTR from January 2010 to July 2011. The effectiveness and safety of EFTR were compared with those of other 34 patients with gastric stromal tumor origination from mus- calaris propria layer who underwent endoscopic submucosal dissection (ESD). Results Except in 2 patients with lesions larger than 3.0 × 3.0 cm, EFTR was successful in others 31 patients, who recovered well and had no recurrence during the follow-up within 12 months. There were no significant differences in resection rate, incidence of complications, body temperature, white blood cell counts or recovery time between 2 procedures (P〉0.05). However, the number of clips used in EFTR (7.0 ±3.5 vs. 4.9 ±3.1, P = 0. 013) and postoperative fasting days (3.4 ±1.5 vs. 2. 0 ± 1.0, P =0. 001 ) were significantly higher than those of ESD procedures. Conclusion EFTR is effective and safe for gastric stromal tumors with no higher risk than ESD, but it is more complex technically. EFTR can be used as an expanding method of ESD in en- doscopic treatment of gastric stromal tumors. Key words: Gastrointestinal stromal tumors ; Therapy ; Endoscopic full-thickness resection ; Endoscopic submucosal dissection

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