Abstract
Background: The endoscopic full-thickness Plicator™ (NDO Surgical, Mansfield MA) delivers a transmural suture at the gastroesophageal junction to restructure the gastric cardia. The resulting tissue plication is intended to accentuate the valvular mechanism of the gastroesophageal junction. Aim: To evaluate the safety and efficacy of the Plicator procedure for the treatment of symptomatic GERD in a cohort of patients followed out from their original participation in a sham-controlled study. Methods: Patients with chronic heartburn and pathologic reflux requiring daily proton pump inhibitor (PPI) therapy were enrolled.
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