Abstract
Objective To study the influencing factors for outcomes of gastric low-grade intraepithelial neoplasia (LGIN) for better LGIN treatment regimen. Methods Using magnifying endoscopy combined with narrow-band imaging (ME-NBI) follow-up strategy, the endoscopic features of 47 cases of LGIN in Fujian Provincial Hospital, including location, size, surface situation, demarcation line, microvascular pattern and microsurface pattern, were prospectively observed, then the factors influencing the outcome were analyzed. Results Among the 47 cases of LGIN, there were 35 cases in stable condition, whose results of biopsy and ME-NBI had no changes (stable LGIN), and the mean follow-up time was 20.7±6.9 months. The remaining 12 patients had progressive dysplasia (progressive LGIN), including 4 cases of high-grade intraepithelial neoplasia, and 8 cases of moderate dysplasia. The mean follow-up time was 16.3±11.8 months. There were no significant differences between the two groups in gender (P=0.33), mean age (P=0.13), lesion distribution (P=0.70), and lesion morphology (P=0.97). The lesion size was less than 20 mm in the stable group (71.4%, 25/35), and over 20 mm in the progressive group (66.7%, 8/12), and the difference was statistically significant (P=0.02). The proportion of the lesion surface heterogeneity in the progressive group was significantly higher than that in the stable group[75.0% (9/12) VS 34.3% (12/35), P=0.01]. The proportion of positive manifestations under ME-NBI in the progressive group was also significantly higher than that in the stable group[83.3% (10/12) VS 8.6% (3/35), P=0.00]. Conclusion The size of lesions over 20 mm, the uneven surface and positive ME-NBI are the important factors influencing the outcome of LGIN, which are of significance for the diagnosis and treatment of LGIN. Key words: Follow-up study; Magnifying endoscopy combined with narrow-band imaging; Low-grade intraepithelial neoplasia; Early gastric cancer
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