Abstract
Food impaction has been described in both eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia. The association between endoscopic/histologic features of esophageal eosinophilia and food impaction remains unclear. We aimed to identify clinical, endoscopic, and histologic findings associated with a history of food impaction in esophageal eosinophilia. This was a retrospective cohort study of adult esophageal eosinophilia patients at a tertiary center in 6/2005-10/2014. Only patients with ≥15 eosinophils/high-power field on mucosal biopsies were included. Demographics, comorbidities, symptoms, endoscopic/histologic findings on initial endoscopy, and history of food impaction were reviewed. Statistical analyses were performed using Fisher's exact test (univariate) and forward stepwise logistic regression (multivariate). 400 patients (42±14years, 61% male) were included, with 78 (20%) having food impaction history. On univariate analyses, rings (62 vs 42%, p=0.003), erosions (12 vs 5%, p=0.03), eosinophil density on biopsy (40 [IQR=30-50] vs 30 [IQR=15-50], p=0.004), and dysphagia (88 vs 62%, p<0.0001) were more prevalent among patients with food impaction history, while heartburn (10 vs 33%, p<0.0001) and abdominal pain (1 vs 12%, p=0.002) were less common. On multivariate analysis, rings (OR 2.6, p=0.002), erosions (OR 3.2, p=0.02), and eosinophil density (β-coefficient=0.01, p=0.04) remained associated with food impaction. Findings of rings and erosions on endoscopy and increased eosinophil density on histology were independently associated with a history of food impaction in adult esophageal eosinophilia patients. Food impaction may result from both active inflammation (erosions and increased eosinophil density) and chronic fibrostenotic changes (rings).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have