Abstract
We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53 (61.6%) were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes.
Highlights
We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients
We found that most of the immunocompetent patients diagnosed with CMV gastroenterocolitis were old and had underlying chronic diseases with or without ongoing acute illnesses
Endoscopic features could be classified into the ulcerative and erythematous types with or without exudate, which were not associated with clinical outcomes
Summary
We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes. CMV remains in a dormant phase for the entire life of an infected individual after the resolution of the initial infection episode This state of latency allows CMV to reactivate when the host’s immunity becomes compromised, such as in the background of acquired immunodeficiency syndrome, organ transplantation, and malignancy treated with chemotherapy[1,2]. The purpose of this study was to investigate the clinical presentation, endoscopic findings, and clinical outcomes of CMV gastroenterocolitis in immunocompetent patients, thereby helping gastroenterologists in making timely diagnosis of and achieving the best treatment outcomes for CMV gastroenterocolitis in immunocompetent patients
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