Abstract
Background: Gastro esophageal reflux disease leads to poor quality of life to patients because of pain and discomfort. Some studies also reported that incidence of adenocarcinoma of esophagus and Barrett's esophagus among patients with reflux disease. The abnormal esophageal motility act as a major risk factors and also reported with severity and prognosis of the disease.
 Material & Methods: In present study 50 patients of heart burn or acid regurgitation (GERD) for at least more than 3 months were enrolled from outdoor and from ward by simple random sampling. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant.
 Results: 15 (30%) had non-erosive reflux disease and 35 (70%) had erosive reflux disease. Among the patients of non-erosive reflux disease, 13 (26%) had normal lower esophageal sphincter pressure and 2 (4%) had Low Lower esophageal sphincter pressure. Among the patients of erosive reflux disease, 32 (64%) had normal lower esophageal sphincter pressure and 3 (6%) had Low Lower esophageal sphincter pressure (P value >0.05). Among the patients of non-erosive reflux disease, 10 (20%) had normal esophageal motility and 5 (10%) had Ineffective esophageal motility. Among the patients of erosive reflux disease, 25 (50%) had normal esophageal motility and 10 (20%) had Ineffective esophageal motility (P value >0.05).
 Conclusion: Low Lower esophageal sphincter and Ineffective or abnormal esophageal motility pressure was non-significantly associated with non-erosive and erosive reflux disease. Ineffective esophageal motility and Low LES pressure was the main cause for gastro esophageal reflux disease
 Keywords: GERD, High Resolution Manometry, Ineffective peristalsis.
Highlights
The burden of gastro esophageal reflux disease (GERD) has reported high prevalence all over worldwide and studies show the geographical variation in occurrence of the disease
Ineffective esophageal motility and Low LES pressure was the main cause for gastro esophageal reflux disease Keywords: GERD, High Resolution Manometry, Ineffective peristalsis
Out of total patients diagnosed with GERD 58% were male and 42% were females
Summary
The burden of gastro esophageal reflux disease (GERD) has reported high prevalence all over worldwide and studies show the geographical variation in occurrence of the disease. Some studies reported that incidence of adenocarcinoma of esophagus and Barrett's esophagus among patients with gastro esophageal reflux disease (2). Patients with abnormal esophageal motility the prevalence of gastro esophageal reflux disease was found upto 40-50% (4). Among the patients of erosive reflux disease, 32 (64%) had normal lower esophageal sphincter pressure and 3 (6%) had Low Lower esophageal sphincter pressure (P value >0.05). Among the patients of non-erosive reflux disease, 10 (20%) had normal esophageal motility and 5 (10%) had Ineffective esophageal motility. Conclusion: Low Lower esophageal sphincter and Ineffective or abnormal esophageal motility pressure was nonsignificantly associated with non-erosive and erosive reflux disease. Ineffective esophageal motility and Low LES pressure was the main cause for gastro esophageal reflux disease Keywords: GERD, High Resolution Manometry, Ineffective peristalsis
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