Abstract
Background:Endoscopic surgery is suitable for the transsphenoidal approach; it is minimally invasive and provides a well-lit operative field. The endoscopic skull base approach through the large opening of the sphenoid sinus through both nostrils has extended the surgical indication for various skull base lesions. In this study, we describe the efficacy and complications associated with the endoscopic skull base approach for extra- or intradural parasellar lesions based on our experiences.Methods:Seventy-four cases were treated by an endoscopic skull base approach. The indications for these procedures included 55 anterior extended approaches, 10 clival approaches, and 9 cavernous approaches. The operations were performed through both the nostrils using a rigid endoscope. After tumor removal, the skull base was reconstructed by a multilayered method using a polyglactin acid (PGA) sheet.Results:Gross total resection was achieved in 82% of pituitary adenomas, 68.8% of meningiomas, and 60% of craniopharyngiomas in anterior extended approach and in 83.3% of chordomas in clival approach, but only in 50% of the tumors in cavernous approach. Tumor consistency, adhesion, and/or extension were significant limitations. Visual function improvements were achieved in 37 of 41 (90.2%) cases. Cerebrospinal fluid (CSF) leakage (9.5%), infections (5.4%), neural injuries (4.1%), and vascular injuries (2.7%) were the major complications.Conclusions:Our experiences show that the endoscopic skull base approach is a safe and effective procedure for various parasellar lesions. Selection of patients who are unlikely to develop complications seems to be an important factor for procedure efficacy and good outcome.
Highlights
Endoscopic surgery is suitable for the transsphenoidal approach; it is minimally invasive and provides a well‐lit operative field
The standard endoscopic transsphenoidal approach has been modified in various ways to develop extended endonasal approaches.[3,6,8]
In 2004, when we had performed the surgery for 84 sellar lesions,[31] we adopted the extended removal for parasellar lesions
Summary
Seventy‐four cases were treated by an endoscopic skull base approach The indications for these procedures included 55 anterior extended approaches, 10 clival approaches, and 9 cavernous approaches. In four tumors extended to cavernous sinus, two cases were nonfunctioning pituitary adenomas and two were growth hormone (GH)‐secreting adenoma that extended beyond the outside line of the internal carotid artery (ICA). All of these tumors required the subarachnoid dissection or cavernous dissection for removal. Hormonal deficit was observed in 4 of the 55 patients with the tumors adjacent to the pituitary gland (1 with pituitary adenoma, 2 with craniopharyngioma, and 1 with Rathke’s cleft cyst) and in 2 of the 9 patients with cavernous sinus tumors; both these patients had GH‐secreting adenomas extending to the cavernous sinus. Seven patients did not present with any clinical symptoms, but their tumor showed growth during the follow‐up period
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