Abstract
We diagnosed lymphoproliferative disorder (LPD) in 29 children who underwent liver transplantion. Ten patients (34.5%) had gastrointestinal involvement. Eight were female. Age ranged from one to 11 years (mean age 4.9 years ±.4) at diagnosis of LPD. Eight patients had polyclonal and two monoclonal LPD. Five have been treated with FK506 and four were converted from CyA to FK506 due to chronic rejection. The first symptoms of LPD occurred from two months to five years after liver transplantion. The presenting symptoms were: fever for more than two weeks with or without anemia (7), GI bleeding (5), abdominal pain (5), diarrhea (5), vomiting and dehydration (2), mouth sore (1). Seven patients have been endoscoped. The results are summarized in the table below. Three of seven patients had multiple sites of GI involvement. Conclusion: The colon is the most commonly involved in patients with LPD post liver transplant followed by the small intestine and the stomach. Both upper and lower endoscopy should be done in each patient to evaluate extent of involvement.
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