Abstract
The chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) has steadily increased and, as a result, adverse effects have become more common. Isolated case reports have documented diaphragm-like colonic strictures and ulceration as the result of NSAID use. We report a unique case of this rare side effect with documented endoscopic and histologic healing of multiple proximal diaphragm-like colonic strictures and ulceration months after simple discontinuation of NSAID therapy.
Highlights
In the United States, the chronic use of nonsteroidal antiinflammatory drugs (NSAIDs) has surfaced as a growing problem
Less is known about NSAIDinduced colopathy, with a range of case reports detailing a spectrum from acute inflammation and ulceration to chronic strictures and fibrosis [4]
Colopathy related to NSAIDs can include nonspecific colitis, colonic ulceration, relapse of inflammatory bowel disease, complications of diverticular diseases including hemorrhage, fistula
Summary
In the United States, the chronic use of nonsteroidal antiinflammatory drugs (NSAIDs) has surfaced as a growing problem. Per a 2010 report, 43 million adults (19.0%) took aspirin at least three times per week for more than 3 months (i.e., regular users), and more than 29 million adults (12.1%) were regular users of NSAIDs, an overall increase of 57% and 41%, respectively, from 2005 [1]. Peptic ulcer disease is a well-known complication of this disease, and this may result in more than 100,000 hospital admissions and more than 7,000 deaths [3]. Less is known about NSAIDinduced colopathy, with a range of case reports detailing a spectrum from acute inflammation and ulceration to chronic strictures and fibrosis [4]
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