Abstract
Summary A β-endorphin analog with replacement of glutamic acid in position 8 by glutamine has been synthesized by modified procedures of the solid-phase method. The analgesic potency of the synthetic analog was increased to nearly three-fold with a concomitant increase of opiate receptor-binding activity in neuroblastoma × glioma hybrid cells. This is the first instance in which a replacement of a single amino acid causes an increase of analgesic potency of β-endorphin.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
