Abstract
One of the most crucial aspects of Ca 2+ signalling is the ability to generate highly localised transient elevations of the cytosolic Ca 2+ concentration at specific strategically important target sites. Inevitably this necessitates a relatively high Ca 2+ buffering power of the cytoplasm, which in turn makes movement of Ca 2+ from one part of a cell to another difficult. Nature has evolved an elegant solution to this problem by creating operational Ca 2+ tunnels through the endoplasmic reticulum. Very recently direct evidence that such tunnelling also occurs in neurons has been provided.
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