Abstract

The clinical characteristic serving as the first clue to the etiologic diagnosis was the lack of response to the various antibiotic regimens utilized. The diagnosis of Mycoplasma gneumoniae infection in these children was made on the basis of elevated mycoplasma complement fixation titers, exclusion of other known respiratory pathogens, and on epidemiologic grounds. The father, who had been symptomatic with respiratory complaints the week before the first child's illness, was found to have a stable, high mycoplasma complement fixation titer. Serious mycoplasmal infections manifested by respiratory distress, mult i lobular pneumonitis, pleural effusion, prolonged fever, and leukocytosis have been described previously in patients with hemoglobinopathies ~~ or dysgammagl0bulinemias.~ There have been no reports of mycoplasmal pulmonary disease of comparable severity in otherwise healthy children. Though severe mycoplasmal disease has been uncommon in children, our experience with these three siblings suggests that the disease spectrum is wider than previously thought, and that severe pulmonary involvement can occur in otherwise healthy children. R E F E R E N C E S

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