Abstract
Propolis has been widely accepted to exhibit immunomodulatory activity. However, the activity during pregnancy has not been investigated yet. This study was a preliminary study that aimed to analyze the effect of several types of Indonesian propolis on the histological changes of maternal mice spleen. A total of 25 pregnant mice were divided into 5 groups, control (1% Tween 80) group, low (380 mg/kg) and high dose (1400 mg/kg) ethanol extract of South Sulawesi propolis groups, and low (380 mg/kg) and high dose (1400 mg/kg) water extract of Banten propolis groups. Propolis samples were administered daily during pregnancy. At day 18 of gestation, the mice were sacrificed to obtain spleen which was used for histological evaluation using hematoxylin and eosin staining. The number and diameter of white pulp were observed under the 10x magnifying of microscope. The results showed that all propolis extracts at low dose significantly increased the number of white pulp (p < 0.05). However, an increase in the diameter was found not significant in all propolis administered groups. This study suggests that Indonesian propolis may modulate maternal immune system.
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