Abstract
The effects of intracerebroventricular administration of endomorphin-1 and endomorphin-2, endogenous μ-opioid receptor agonists, on passive avoidance learning associated with long-term memory were investigated in mice. Endomorphin-1 (10 and 17.5 μg) and endomorphin-2 (17.5 μg) produced a significant decrease in step-down latency in a passive avoidance learning task. β-Funaltrexamine (5 μg) almost completely reversed the endomorphin-1 (17.5 μg)- and endomorphin-2 (17.5 μg)-induced shortening of step-down latency, although neither naltrindole (4 ng) nor nor-binaltorphimine (4 μg) produced any significant effects on the effects of endomorphins 1 and 2. These results suggest that endomorphins 1 and 2 impair long-term memory through the mediation of μ-opioid receptors in the brain.
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