Abstract
The present study was designed to examine the effects of the endogenous μ-opioid receptor agonist endomorphin-1 on prepulse inhibition (PPI) in mice. Although apomorphine (1 mg/kg) produced a marked decrease in PPI, endomorphin-1 (17.5 μg) had no marked effects on PPI or startle amplitude in normal mice. Endomorphin-1 (17.5 μg) inhibited the apomorphine (1 mg/kg)-induced decrease in PPI. β-Funaltrexamine (5 μg), a μ-opioid receptor antagonist, did not significantly antagonize the effects of endomorphin-1 (17.5 μg). Naloxonazine (35 mg/kg), a μ 1-opioid receptor antagonist, antagonized the effects of endomorphin-1 (17.5 μg) on the apomorphine (1 mg/kg)-induced decrease in PPI, whereas naloxonazine (35 mg/kg) itself was without significant effects on the apomorphine (1 mg/kg)-induced decrease. These results suggest that endomorphin-1 alleviates the impairment of PPI resulting from the hyperactivity of dopaminergic neurotransmission through the mediation of μ 1-opioid receptors.
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