Endometriosis-associated ovarian cancer

S A Levakov,A G Kedrova,T A Gromova,N A Sheshukova

doi:10.17650/1994-4098-2016-12-4-47-51

Abstract

This article reviews recent advance in our understanding of ovarian endometriomas, with special reference of atypical epithelial features (atypical endometriosis) and its relationship to neoplasm. Mainly, two epithelial ovarian carcinoma subtypes, the ovarian clear cell carcinomas and the endometrioid ovarian carcinomas, have been molecularly and epidemiologically linked to endometriosis. The clear cell and endometrioid adenocarcinomas have common immunohistochemical markers, genetic changes are the same as atypical endometriosis. The occurrence of ARID1A mutations and alterations in the PI3K/AKT pathway in endometriosis and endometriosis-associated ovarian carcinomas, as well as the possible functional and clinical implications are discussed in this review. Therefore, development of a screening method that can detect mutations of ARID1A and activation of the PI3K/AKT pathway might enable early diagnosis of endometriosis associated ovarian cancers and endometrial cancers.

Highlights

The occurrence of ARID1A mutations and alterations in the PI3K/AKT pathway in endometriosis and endometriosis-associated ovarian carcinomas, as well as the possible functional and clinical implications are discussed in this review
Yamamoto S., Tsuda H., Takano M. et al PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma

Summary

Эндометриозассоциированный рак яичников

2; 2кафедра акушерства и гинекологии ФГБОУ ДПО «Институт повышения квалификации ФМБА России»; Россия, 125371 Москва, Волоколамское шоссе, 91. Ключевые слова: эндометриоз, светлоклеточный рак яичников, эндометриоидный рак яичников, ген-супрессор ARID1A, генсупрессор PTEN, PI3K / AKT-сигнальный путь рака яичников. The occurrence of ARID1A mutations and alterations in the PI3K/AKT pathway in endometriosis and endometriosis-associated ovarian carcinomas, as well as the possible functional and clinical implications are discussed in this review. Development of a screening method that can detect mutations of ARID1A and activation of the PI3K/AKT pathway might enable early diagnosis of endometriosis associated ovarian cancers and endometrial cancers. Однако данные крупных эпидемиологических исследований, подтвердившие 2,5‐кратный риск развития рака при 10‐летнем наблюдении за женщинами с эндометриозом, появились только в конце ХХ в. При этом до сих пор нет четкого патогенетического понимания развития болезни и полноценного

ОДибазогнронсытеисктаатьи а б

Эндометриоидная аденокарцинома

Хромосомные амплификации