Abstract

BackgroundClinico-pathological characteristics and possible prognostic factors among women with epithelial ovarian carcinoma (EOC) with or without concurrent endometriosis were explored.MethodWe retrospectively identified 304 patients with EOC treated primarily at Peking Union Medical College Hospital with median follow-up time of 60 months.ResultsOf 304 patients with EOC, concurrent endometriosis was identified in 69 (22.7%). The patients with concurrent endometriosis were younger and more probably post-menopausal at onset, were less likely to have abdominal distension, with significantly lower level of pre-surgery serum Ca125 and less possibility of having the history of tubal ligation. The women with concurrent endometriosis group were more likely to have early stage tumors (88.41% versus 52.77%), receive optimal cytoreductive surgery (92.75% versus 71.06%), and less likely to have lymph node metastasis or to develop platinum resistance disease (7.25% versus 14.89%, and 7.35% versus 20%), when compared with women without coexisting endometriosis. The univariate analysis showed that concurrent endometriosis was a prognostic factor for overall survival (OS) and disease-free survival (DFS), but this association just remained in the DFS by multivariate analysis. Besides, multivariate analysis also showed that FIGO stage, residual disease, chemotherapy cycles, chemotherapy resistance and concomitant hypertension were the independent impact factors of OS for EOC patients; whereas FIGO stage, lymphadenectomy, residual disease, coexisting endometriosis and chemoresistance were independent impact factors of DFS for those patients.ConclusionsEOC patients with concurrent endometriosis showed distinct characteristics and had longer overall survival and disease-free survival when compared with those without endometriosis. Endometriosis was the independent prognostic factor for DFS for patients in this series.

Highlights

  • Clinico-pathological characteristics and possible prognostic factors among women with epithelial ovarian carcinoma (EOC) with or without concurrent endometriosis were explored

  • According to the pathological criteria listed above, we identified 68 of patients with ovarian carcinoma with concurrent EM (EAOC group), The remaining 236 patients had no pathological evidence of endometriosis

  • Similar to the results of numerous studies [18,19,20], we found that most ovarian clear cell carcinoma (OCCC) and ovarian endometrioid carcinoma (OEC) patients of the Endometriosisassociated ovarian cancer (EAOC) group (71.01%) had Federation of Gynecology and Obstetrics (FIGO) I stage cancer at diagnosis

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Summary

Introduction

Clinico-pathological characteristics and possible prognostic factors among women with epithelial ovarian carcinoma (EOC) with or without concurrent endometriosis were explored. Endometriosis (EM) is one of the most common benign gynecological diseases, with an incidence as high as 10– 15% in women of childbearing age. EM typically manifests as masses, pain, and infertility in clinical practice, seriously affecting physical and psychological health as well as the quality of life of women of childbearing age. Ren et al Journal of Ovarian Research (2017) 10:67 NON-EAOC EAOC P. 45.00 [40.00,49.50]

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