Abstract
Endometriosis is a silent, unseen and painful female illness which is characterized by the presence of glands and stroma outside the uterine cavity. Approximately one in ten women in a reproductive age around the world suffer from endometriosis of whom nearly half is treated due to infertility. The pathogenesis and mechanisms that determines the occurence of the disease are still unknown. Immunological factors have been observed in the initiation and development of endometriosis. An imbalance between reactive oxygen species (molecules having an unpaired electron) and antioxidants leads to the upregulation of metalloproteinases, prostaglandins, cytokines and chemokines.
Highlights
Endometriosis is a common gynecological disorder with features of chronic inflammation
Mental disturbances may express as a various form of anxiety and depression
Purpose of this work This study aimed to discuss the potential role of flavonoids, N-acetylcysteine and curcumin in endometriosis by acting on inflammation and oxidative stress
Summary
Endometriosis is a common gynecological disorder with features of chronic inflammation. Irregular uterine bleeding, dyspareunia are main symptoms which has a negative impact on mental and physical health [1]. An additional problem, which leads to a deterioration in the emotional condition of the patients is infertility [2]. It is estimated that evolution of the disease has a negative influence on the quality of life in approximately one third of the patients. The attitude of patients towards the disease and its course, acceptance of life with a chronic disease seems important [3]. 2. Purpose of this work This study aimed to discuss the potential role of flavonoids, N-acetylcysteine and curcumin in endometriosis by acting on inflammation and oxidative stress
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