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Abstract
Endometriosis is an inflammatory oestrogen-dependent chronic disease and is mainly expressed by pain and increased infertility. Several studies showed an increased prevalence of autoimmune systemic diseases and various autoantibodies in endometriosis. The association of these autoimmune markers and diseases could raise the fact that endometriosis is an authentic autoimmune or inflammatory disease and thus could argue for the use of immunomodulatory therapies. Usually, it is considered that the autoantibodies did not directly act in endometrium implants growth, and could be rather implicated in endometriosis-related infertility. The use of immunomodulatory strategies could be an important alternative or additional strategy to the use of hormones and surgery but need prospective well-designed trials.
Highlights
Endometriosis is an inflammatory oestrogen-dependent disease characterized by extra-uterine infiltration of endometrial glands and stroma [1]
This review aims to describe the prevalence of autoimmune diseases associated with endometriosis, the prevalence of various autoantibodies, and the perspectives of immunomodulatory therapies
When the analysis was restricted to 9,191 women with laparoscopy or laparotomy confirmed endometriosis, associations were significant for multiple sclerosis (MS) (SIR = 1.4; 95% confidence interval (CI) 1.04–1.9), but not for systemic lupus erythematosus (SLE) (SIR = 1.1; 95% CI 0.6–2.1) and primary SS (pSS) (SIR = 1.4; 95% CI 0.9–2.3)
Summary
Cite this article: Abisror N, Kolanska K, Cheloufi M, Selleret L, d’Argent E, Kayem G, et al Endometriosis and autoimmunity.
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