Abstract
Endometriosis is associated with imbalances of the endocannabinoid system (ECS) which correlate with symptoms: Whereas cannabinoid receptors CB1 and CB2 are downregulated, plasma levels of endocannabinoids (AEA, 2-AG and PEA) are elevated. In addition, levels of matrix metalloproteinases (MMPs) which are important for a wide range of pathological processes including spreading of cells and inflammation are also high in ectopic endometrium. Cannabinoids including cannabidiol (CBD) are known to interact wit the ECS. Among other mechanisms, they decrease MMP production and therefore invasiveness of cells.
Highlights
The Endometriosis is the presence of endometrial tissue outside the uterine cavity in sites such as the ovaries, pelvic peritoneum, and the rectovaginal septum
Endometriosis is associated with imbalances of the endocannabinoid system (ECS) which correlate with symptoms: Whereas cannabinoid receptors CB1 and CB2 are downregulated, plasma levels of endocannabinoids (AEA, 2-AG and PEA) are elevated
Levels of matrix metalloproteinases (MMPs) which are important for a wide range of pathological processes including spreading of cells and inflammation are high in ectopic endometrium
Summary
The Endometriosis is the presence of endometrial tissue outside the uterine cavity in sites such as the ovaries, pelvic peritoneum, and the rectovaginal septum. Endometriosis is associated with imbalances of the endocannabinoid system (ECS) which correlate with symptoms: Whereas cannabinoid receptors CB1 and CB2 are downregulated, plasma levels of endocannabinoids (AEA, 2-AG and PEA) are elevated. As endometrial cells have a hyperproliferative phenotype and pro-angiogenic properties, it may be argued that the decrease of MMPs by CBD could reduce endometriosis.
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