Abstract
Endometrial stromal nodules are rare. They represent less than a quarter of endometrial stromal tumors. Clement and Scully described as variants of endometrial stromal nodules two types of tumor ressembling ovarian sex cord tumors. Type I is tumor that resembles focally an ovarian sex cord tumor which can be abbreviated ESTSCLE, or endometrial stromal tumors with sex cord-like elements and type II; uterine tumors with more than 40% sex cord-like differentiation so called UTROSCT for uterine tumor resembling ovarian sex cord tumor. Uterine tumours with sex cord-like differentiation are very rare with only 50 cases reported in the literature so far. The diagnostic is based on microscopic findings. Immunohistochemical tests to elucidate their nature yield variable and polyphenotypic with coexpression of markers of epithelial, myoid and sex cord lineage as well as hormone receptors. We report an additional case of an endometrial stromal tumors with sex cord-like elements in a 48-year-old woman presenting with abnormal mass.
Highlights
IntroductionThey represent less than a quarter of endometrial stromal tumors [1]
Endometrial stromal tumors with sex cord-like elements have an unfavorable prognosis; and the uterine tumor resembling ovarian sex cord tumor UTROSCT containing more than 40% sex cord-like differentiation and less endometrial component are biologically less aggressive
Tumors of the uterus resembling ovarian sex cord tumors were reported by Clement and Scully in 1976 and were divided in 2 groups [2] accounding of the share of sex cord-like elements
Summary
They represent less than a quarter of endometrial stromal tumors [1] This benign tumour can resemble, at least focally, an ovarian sex cord tumor. The tumor is well circumscribed contour, measuring 11x10x8cm and have fleshy yellow surface (Figure 2). This tumor is intramural with no connection to the endometrium. In microscopic findings the tumor consist of cells that closely resemble normal proliferative-phase endometrial stromal cells with areas of epithelial-like structures that have an appearance reminiscent of an ovarian sex cord-stromal tumor. The epithelial-like cells grow in cords and trabeculae, they are cuboidal with scanty amphophilic cytoplasm and nuclei resemble those of the surrounding stromal cells (Figure 3). Immunostaining for AML, desmine, calretinin, cytokeratin AE1/AE3 and inhibin was negative
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