Endometrial regeneration in Asherman's syndrome and endometrial atrophy using Wharton's jelly-derived mesenchymal stem cells.

Abstract

Reconstruction of the endometrium in patients with endometrial atrophy and Asherman's syndrome using Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs). Prospective pilot study, with the inclusion of two patients. After administration of WJ-MSCs into the uterine cavity, endometrial reconstruction was achieved in both patients. Pregnancy was achieved in one of them, after transfer of a frozen embryo, completed by delivery around the due date. Endometrial atrophy and Asherman's syndrome, is one of the most frustrating clinical situations we face in assisted reproductive procedures. The use of Wharton's jelly-derived mesenchymal stem cells in restoring the normal function of the endometrium, could become an easy and accessible therapeutic medal, for this endometrial dysfunction, which is so difficult to treat.