Abstract
Many molecular markers have been identified in different stages of the luteal phase those play roles in the implantation. Our aim was to compare the levels of insulin-like growth factor binding protein 1 (IGFBP-1), Osteopontin (OPN) and prostaglandin E2 (PGE2) in endometrial washing liquid between women with ovulatory polycystic ovary syndrome (PCOS), endometrioma and unexplained subfertility, compared with ovulatory women. The study groups were formed by women with ovulatory PCOS (n=24), endometrioma (n=17) and unexplained subfertility (n=25). The control group consisted of fertile women (n=18). There were no significant differences in terms of the values of IGFBP1, PGE2 and OPN among groups. There was a statistically significant difference between ovulatory PCOS group and control group in terms of PGE2 levels (p=0.002). High PGE2 might be a marker for poor endometrial receptivity. We supposed that the down-regulation of PGE2 may facilitate decidualization and improve pregnancy rate in ovulatory PCOS.
Highlights
A successful embryo implantation requires a receptive endometrium, a live embryo and harmonious signalization between them
What The Results Of This Study Add: High prostaglandin E2 (PGE2) levels in women with ovulatory polycystic ovary syndrome (PCOS) may contribute to endometrial dysfunction and subfertility according to results of our study
What Are The Implications Of These Findings Clinical Practice And/Or Further Research: PGE2 may be an indicator of reduced endometrial receptivity that might be responsible for the low pregnancy rates in women with ovulatory PCOS
Summary
A successful embryo implantation requires a receptive endometrium, a live embryo and harmonious signalization between them. After the contact between cytokines, growth factors, receptors and blastocyst, junctional complexes are formed. Blastocyst adhesion and invasion starts via adhesion molecules such as integrins and selectins [1]. The implantation window is defined as that period when the uterus is receptive for implantation of the free-lying blastocyst. Some important growth changes occur during implantation window. Many molecular markers have been identified in different stages of the luteal phase those play roles in the implantation. These endometrial receptivity markers are expressed in the implantation window for successful implantation [2,3,4,5]
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