Endometrial pattern change from the start of progesterone administration to day of embryo transfer as predictor of endometrial receptivity in donor oocyte cycles

Abstract

ObjectiveEndometrial pattern changes from a triple-layer (T) to hyperechogenic (H) type following progesterone (P4) administration were shown to predict pregnancy in autologous cycles. Our objective was to investigate the effect of endometrial pattern transformational changes in relation to pregnancy outcomes in donor oocyte cycles.DesignRetrospective study.Materials and MethodsThis study included 166 IVF/embryo transfer (ET) donor oocyte cycles performed between 2007 and 2010. Oocyte donor's mean age was 27.6 ± 3.9 years. Oocyte donors underwent ovarian stimulation with FSH and hMG after long GnRH protocol. Embryo recipients were synchronized using long acting GnRH agonist following by fixed dose of oral estrogen and P4. Endometrial ultrasound assessment was performed both on P4 administration day and ET day.ResultsTabled 1Endometrial pattern change is related to endometrial receptivity in donor oocyte cycles.Endometrial Pattern Changes# of PatientsOocyte donor age# of Clinical Pregnancy# of live birth and on-going pregnancyT-H13627.7 ± 3.8103 (76%)93(68%)T-T1127.5 ± 5.48 (73%)6 (55%)H-H1927.2 ± 4.210(53%)*9(47%)Fisher's exact test P=0.015 compared to T-H and T-T. Open table in a new tab ConclusionEndometrial T-H pattern transformation change appears to be associated with the most favorable pregnancy outcomes. The H-H pattern has the greatest negative impact on clinical pregnancy rate; yet it may still yield a reasonable pregnancy outcome. Further data is required to investigate the impacts of T-T pattern on live birth. These results may be useful in counseling patients undergoing donor oocyte cycles. ObjectiveEndometrial pattern changes from a triple-layer (T) to hyperechogenic (H) type following progesterone (P4) administration were shown to predict pregnancy in autologous cycles. Our objective was to investigate the effect of endometrial pattern transformational changes in relation to pregnancy outcomes in donor oocyte cycles. Endometrial pattern changes from a triple-layer (T) to hyperechogenic (H) type following progesterone (P4) administration were shown to predict pregnancy in autologous cycles. Our objective was to investigate the effect of endometrial pattern transformational changes in relation to pregnancy outcomes in donor oocyte cycles. DesignRetrospective study. Retrospective study. Materials and MethodsThis study included 166 IVF/embryo transfer (ET) donor oocyte cycles performed between 2007 and 2010. Oocyte donor's mean age was 27.6 ± 3.9 years. Oocyte donors underwent ovarian stimulation with FSH and hMG after long GnRH protocol. Embryo recipients were synchronized using long acting GnRH agonist following by fixed dose of oral estrogen and P4. Endometrial ultrasound assessment was performed both on P4 administration day and ET day. This study included 166 IVF/embryo transfer (ET) donor oocyte cycles performed between 2007 and 2010. Oocyte donor's mean age was 27.6 ± 3.9 years. Oocyte donors underwent ovarian stimulation with FSH and hMG after long GnRH protocol. Embryo recipients were synchronized using long acting GnRH agonist following by fixed dose of oral estrogen and P4. Endometrial ultrasound assessment was performed both on P4 administration day and ET day. ResultsTabled 1Endometrial pattern change is related to endometrial receptivity in donor oocyte cycles.Endometrial Pattern Changes# of PatientsOocyte donor age# of Clinical Pregnancy# of live birth and on-going pregnancyT-H13627.7 ± 3.8103 (76%)93(68%)T-T1127.5 ± 5.48 (73%)6 (55%)H-H1927.2 ± 4.210(53%)*9(47%)Fisher's exact test P=0.015 compared to T-H and T-T. Open table in a new tab Fisher's exact test P=0.015 compared to T-H and T-T. ConclusionEndometrial T-H pattern transformation change appears to be associated with the most favorable pregnancy outcomes. The H-H pattern has the greatest negative impact on clinical pregnancy rate; yet it may still yield a reasonable pregnancy outcome. Further data is required to investigate the impacts of T-T pattern on live birth. These results may be useful in counseling patients undergoing donor oocyte cycles. Endometrial T-H pattern transformation change appears to be associated with the most favorable pregnancy outcomes. The H-H pattern has the greatest negative impact on clinical pregnancy rate; yet it may still yield a reasonable pregnancy outcome. Further data is required to investigate the impacts of T-T pattern on live birth. These results may be useful in counseling patients undergoing donor oocyte cycles.