Abstract
Copper-containing intrauterine devices such as the endouterine Copper T (CuT) first developed by Zipper and Tatum appear to offer great promise. The clinical effectiveness of these devices and their low rate of associated side effects such as expulsion, bleeding, and cramping compare favorably with other devices. The antifertility effect of the CuT is believed to be related to the metallic copper covering. Experimental data suggest that a local, rather than a systemic, contraceptive mechanism is operative due either to direct spermatocidal action, the inhibition of implantation, or a combination of these. The present study was undertaken to extend the electron microscopic studies of CuT-IUCD-bearing endometria using both scanning and transmission electron microscopy and to examine copper distribution utilizing an energy dispersive X-ray analyzer.
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