Abstract
Currently, unlike in the past, the endometrial cavity is not considered to be sterile. The endometrium is supposed to be dominated by Lactobacilli, but also their deficiency can be found in the reproductive tract of asymptomatic healthy women. Sometimes the endometrial microbiome is dominated by various pathological microorganisms, and this can lead to various conditions as chronic endometritis, chorioamnionitis and preterm birth. Their presence causes uterine inflammation and infection, release of pro-inflammatory molecules, uterine contractions, disruption of cervical barrier, premature rupture of membranes. Uterine dysbiosis is associated with recurrent implantation failure and recurrent miscarriages. As the microbiome is important for maintaining immunological homeostasis at the level of gastrointestinal tract Lactobacilli may play a similar function at the level of uterus. The lactobacillus-dominated uterine microbiome is of great importance for maintaining a hostile uterine microenvironment, embryo implantation, early pregnancy development and normal pregnancy outcome.
Highlights
Unlike in the past, the endometrial cavity is not considered to be sterile
Sometimes the endometrial microbiome is dominated by various pathological microorganisms, and this can lead to various conditions as chronic endometritis, chorioamnionitis and preterm birth
Non-Lactobacillus-dominated microbiome can be found in the reproductive tract of asymptomatic physically healthy women, which suggests it may be assumed as a norm.[5]
Summary
Severe chorioamnionitis is found on the fetal side of the placenta with colonization by Corynebacterium species, Escherichia coli, Peptostreptococcus magnus, Prevotella bivia, Streptococcus species and genital mycoplasmas.[41,54,60,61,62] These bacteria may result from the ascension of microorganisms from the vagina and uterine colonization.[63] Their development on chorion and amnion induces immunological and inflammatory changes which can cause an early rupture of the membranes In this case, antibiotic therapy is highly recommended because it reduces chorioamnionitis, prolongs the time to birth at full term, and reduces neonatal infections.[64] Preeclampsia. The association of polymicrobial communities and preeclampsia is based on the triggering inflammatory and antiangiogenic activity with subsequent impaired trophoblastic and endothelial function and increased blood pressure
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.