Endometrial Hyperplasia in Polycystic Ovarian Syndrome Patients Having Raised Endometrial Thickness

Abstract

Objective: To determine the frequency of endometrial hyperplasia in polycystic ovarian syndrome patients having raised endometrial thickness at tertiary care Hospital. Study Design: Cross Sectional Study. Settings: Study was conducted at obstetrics and gynaecology department of Dow University Hospital Karachi Pakistan. Duration: Six months from November 2015 to May 2016. Methodology: Both primary and secondary infertile women having polycystic ovarian syndrome (PCOS) with raised endometrial thickness, age between 18-45 years and willing to participate in the study were included. Patients were evaluated during first week in follicular phase. For evaluating endometrial thickness (ET) of patients, endometrial biopsy and transvaginal sonography were done. Endometrial tissues were taken from patients and were sent to diagnostic laboratory for histopathology and endometrial hyperplasia assessment. All the data was recorded in self-made proforma and analysed by SPSS version 20. Results: Total 90 patients were studied; their mean age was 28.6+4.56 years, with mean duration of infertility as 5.15+1.4 years. Endometrial hyperplasia among patients of polycystic ovarian syndrome was 31.1%. Age >29 years, infertility >5 years, diabetes and smoking were significantly associated with endometrial hyperplasia, (P=0.001). There was no significant impact of BMI, parity and hypertension on frequency of endometrial hyperplasia; p-values were quite insignificant. Conclusion: In the polycystic ovarian experiencing women with raised endometrial thickness, the endometrial hyperplasia was 31.1%. Elevated age, prolonged duration of infertility, diabetes and smoking may be risk factors of endometrial hyperplasia.