Abstract
Endometrial biopsies were obtained from eleven volunteers bearing a progesterone-releasing intrauterine device (IUD). The mean treatment time was 4.1 yrs (range 1–5 yrs). Tissue samples were collected during the follicular phase of the cycle and assayed for estrogen and progestin receptors with [ 3H]estradiol and [ 3H]ORG 2058 (16α-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione) as the respective radioactive ligands. Both receptor values were significantly lower (p < 0.01) than those present in endometrial tissue of normally menstruating women. The steroid receptor concentrations measured (estrogen receptor 19.6 ± 9.9 and progestin receptor 134.4 ± 121.4 fmol/mg cytosol protein) from women with an IUD represented only about 20 % of those in endometria of normal women. This result suggests that progesterone released from the IUD has a depressive action on the sex steroid receptor levels which may contribute to the contraceptive effectiveness of the IUD.
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