Abstract
Endometrial cancer is the most common gynecological cancer and is a disease of postmenopausal women. The disease appears in 20 years or less extremely rare. Four case of endometrial cancer in 20 years old or less female, treated at Department of Gynecological Oncology, National Oncologic Hospital, Sofia, Bulgaria (1991-2009) are presented. The surgery mode and postoperative treatment was according the stage and histological type of the tumors. These patients were Stage IA, and one patient was Stage IIIC. A follow-up period till 31 December 2012 all the patients are free of disease.
Highlights
Endometrial cancer is the most common gynecological cancer and is a disease of postmenopausal women
Conservative treatment is indicated for young women stage I, high-differentiated adenocarcinoma who want to keep childbirth potential
Women under 40 who are not obese are at higher risk of both advanced disease and high-risk histology [5]
Summary
Endometrial cancer is the most common gynecological cancer and is a disease of postmenopausal women. Risk factors for endometrial cancer are: increasing age, long-term exposure to unopposed oestrogens, residence in North America or Europe, high concentrations of oestrogens postmenopausally, metabolic syndrome (obesity, diabetes), years of menstruation, nulliparity, history of breast cancer, long-term use of tamoxifen, HNPCC family syndrome, hormone-replacement therapy with less than 12–14 days of Progestagens, first-degree relative with endometrial cancer [9]. These patients usually present with estrogen or hormone-related disorders such as nulliparity, obesity, and infertility. Women under 40 who are not obese are at higher risk of both advanced disease and high-risk histology [5]
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