ENDOMETRIAL BIOPSIES PATTERNS AMONG WOMEN ATTENDING MOI TEACHING AND REFERRAL HOSPITAL, KENYA

Abstract

Background: Endometrial diseases are among the most common gynecological disorders affecting women both globally and locally;accounting for 60% of global maternal deaths.Kenya is ranked thirteenth out of 181 countries with the highest maternal mortality globally. Endometrial disorders such as hyperplasia's, neoplastic, inflammatory and pregnancy related conditions of the endometrium have been reported to increase with demographic traits such as maternal age and parity. Objective: To determine histopathological patterns of endometrial biopsies among women attending Moi Teaching and Referral Hospital,Kenya. Methods: This was a retrospective laboratory-based study where 121 banked endometrial biopsy blocks collected from participants aged 19 to 70 years between August 2014 and August 2016 were retrieved, re-sectioned and stained using routine histological (Hematoxylin and Eosin) stains in the histology laboratory before being sent to the pathologist for examination. Sociodemographic and reproductive history data were collected from the medical records. Descriptive statistical techniques such as cross-tabulation were used.The median age of all the study participants was 44 years. Results: Most of the study participants (39.2%;n=38) presented with simple endometrial hyperplasia.The endometrial patterns were categorized as Hyperplasias (50.4%; n=61), Inflammatory disorders (7.4%; n=9), Neoplastic Disorders (14.9%;n=18),Pregnancy related disorders (20.7%;n=25) and other patterns (6.6%;n=8) Conclusion: Majority of the study participants presented with simple endometrial hyperplasia followed by complex hyperplasia and adenocarcinoma,respectively.