ENDOGRADE: A four level classification to rate surgical complexity in endometriosis.

Abstract

We studied a post operative classification of surgical complexity in endometriosis. Retrospective monocentric observational study was conducted between January 2001 to December 2019 and included 764 women with DE that underwent surgery. We retrospectively graded surgical complexity through operative reports according to the ENDOGRADE classification, that grades the surgical complexity of DE in four progressive levels. Operating time was longer for patients rated ENDOGRADE 3 (228±93min) compared to patients rated ENDOGRADE 2 (120± 51min) (p<10-3) and for patients rated ENDOGRADE 4 (301±99min) compared to patients rated ENDOGRADE 3 (228±93min), (p<10-3). Eighty percent (20/25) of peroperative complications were rated ENDOGRADE 3 or 4, 20% (5/25) were rated ENDOGRADE 1 or 2 (p=0.01). Patients rated ENDOGRADE 2, 3 and 4 were 10.3 times (95CI=2.4-44.9, p=2.10-3), 12.2 times (95CI=2.9-50.2, p=5.10-4) and 38.3 times (95CI=9.1-162, p=7.10-7) more likely to experience postoperative complications than those rated ENDOGRADE 1. According to multivariate analysis, only patients rated ENDOGRADE 2, 3, and 4 had a significantly higher risk of postoperative complications with an OR=16.0 (95CI=2.0-127.4, p=9.10-3), OR=16.2 (95CI=1.6-159.7, p=0.02) and OR=104.2 (95CI=24.6-440.5, p=4.10-3), respectively. ENDOGRADE classification of surgical complexity in DE is correlated to operating time, per- and post-operative complications.