Abstract
Background:Microvascular proliferation is a major risk factor for plaque vulnerability in patients with carotid stenosis. There are several vascular endothelial markers such as CD31 and CD105, but it is unclear which marker is most sensitive for microvessels. This study sought to examine the correlations between CD31 and CD105 expression in microvessels on carotid plaques and clinical manifestations.Methods:We studied 13 lesions in 12 patients. The patients underwent carotid endarterectomy and samples were stained for CD31 and CD105. The numbers of microvessels positive for these markers within a field of view were counted.Results:The average numbers of microvessels were 5.8 ± 5.4 for CD31 and 9.2 ± 9.3 for CD105 (P = 0.04). More microvessels were positive for CD105 than there were for CD31 in patients with diabetes mellitus (P = 0.04).Conclusion:In patients with carotid artery stenosis, CD105 is more appropriate than CD31 for detecting microvessels in carotid plaques. In patients with diabetes mellitus, CD105 is significantly more highly expressed in microvessels than CD31.
Highlights
ObjectivesThe aim of this study was to compare the expression of CD31 and CD105 in microvessels of carotid artery plaques and to assess the relationships between their expression levels and clinical characteristics
Microvascular proliferation is a major risk factor for plaque vulnerability in patients with carotid stenosis
Several studies such as the North American Symptomatic Carotid Endarterectomy Trial (NASCET)[4] and the European Carotid Surgery Trial (ECST)[24] have demonstrated that the rate of stenosis is related to the risk of cerebral infarction
Summary
The aim of this study was to compare the expression of CD31 and CD105 in microvessels of carotid artery plaques and to assess the relationships between their expression levels and clinical characteristics
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