Abstract
Purpose: C-X-C chemokine receptor type 7 (CXCR7) is defined as a chemokine receptor able to bind the several endogenous ligands stromal cell-derived factor 1/C-X-C motif chemokine 12 (SDF1/CXCL12), IFN-inducible T cell α-chemoattractant (I-TAC/Cxcl11), macrophage inhibitory factor (Mif), and adrenomedullin (Adm). CXCR7 has a 10-fold higher binding affinity for SDF1 than CXCR4 well known for another receptor of SDF1. Though the important roles of the SDF1/CXCR4 axis have been elucidated, the SDF1/CXCR7 axis remains still obscure in chondrocyte inflammation.
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