Endogenous renal clearance rates of free amino acids in prolinuric and Hartnup patients.

Abstract

Endogenous renal clearance rates of free amino acids were determined by use of automatic amino acid analyzer on ten control children, two patients with prolinuria and a Hartnup patient. Prolinuric patients showed markedly high rates in the proline and glycine clearance and almost normal clearance rates in the other amino acids. In a Hartnup patient, the clearance rates of monoamino-monocarboxylic amino acids were found to be highly elevated.