Endogenous progenitors as the source of cell material for ischemic damage repair in experimental myocardial infarction under conditions of changed concentration of vascular endothelial growth factor.

M G Shurygin,I A Shurygina,O V Kanya,N N Dremina

doi:10.1007/s10517-015-2801-4

Endogenous progenitors as the source of cell material for ischemic damage repair in experimental myocardial infarction under conditions of changed concentration of vascular endothelial growth factor.

M G Shurygin, I A Shurygina + Show 2 more

https://doi.org/10.1007/s10517-015-2801-4

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Journal: Bulletin of experimental biology and medicine	Publication Date: Feb 1, 2015
Citations: 8

Affiliation: Russian Academy of Sciences

#Experimental Myocardial Infarction #Regeneration Zone + Show 8 more

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Abstract

We studied the effect of VEGF-A in experimental myocardial infarction on attraction of progenitor cells into the regeneration zone. The appearance of CD34(+)CD45(+) cells known as low-differentiated progenitor cells was observed in the damaged myocardial tissue in the presence of a considerable excess of VEGF-A. These cells can act as precursors of mesenchymal tissues depending on the direction of differentiation.

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