Abstract
The effects of endogenous opiates on hormonal responses to oral glucose challenge were determined in noninsulin- dependent diabetics (NIDD). In one group of subjects, facial flushing occurred in response to the administration of alcohol and chlorpropamide. The facial flushing response can be produced by an opioid peptide analog and can be blocked by naloxone. Such chlorpropamide alcohol flushing (CPAF)-positive patients are thought to represent a significant subset (>one third) of all NIDD patients who may have different severity and incidence of diabetic complications than patients who do not flush (CPAF negative). Nine NIDD patients who had never been treated with insulin and were not massively obese (<150% of ideal body weight) were studied. Five NIDD patients were found to be CPAF positive and four CPAF negative based on thermistor- measured changes in facial temperature after the administration of 250 mg chlorpropamide and 45 cc sherry wine. After 3 days on an 1800-cal/m2, 40% carbohydrate diet, all ...
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