Abstract
Gliomas are the major tumour entity of the central nervous system. The term glioma implies that these cells may originate from glial cells, although this has not been proven. Recent evidence indicates an interaction and interrelationship of glioma cells with stem cells. Neural stem cells generate all neurons, astrocytes and oligodendrocytes of the developing brain. They persist through adulthood in two specialized stem cell niches. A number of recent studies suggest that altered proliferation and differentiation of neural stem and precursor cells could be the primary source for glioma. Previously, it was demonstrated that cultured, immortalised neural precursors display tropism for gliomas, and that such precursors exert an anti-tumourigenic effect on glioma.
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