Abstract
The aim of the work was to analyze the indices of endogenous intoxication in deep-pregnant cows and to identify the possibilities of their use as predictors of bronchopulmonary pathology in newborn calves. 29 cows were examined for 239-262 days of gestation and 29 newborn calves of the red-and-white Holstein breed. Bronchitis developed in all calves during the first month of life, and in 7 newborns it was complicated by pneumonia. Markers of endogenous intoxication of cows were analyzed: total and effective albumin concentration, serum MMP content, Kalf-Kalif leukocyte index of intoxication (LII); toxicity index (IT), the ratio of intoxication (CI). The MMP level in cows whose calves did not develop pneumonia was 0.4080.152 units. Cows whose calves developed pneumonia showed a significantly higher content of SMP (0.6150.977 units, p 0.05). Correlation between the concentration of the MMP and the probability of pneumonia (rs=0.536, p0.005) was found. The leukocyte intoxication index of Kalf-Kalif and the toxicity index (IT) in both groups of cows varied significantly; no differences between groups were found. The coefficient of intoxication in cows whose calves developed pneumonia (CI=26.58.4), statistically significantly (p0.05) exceeded CI in cows whose offspring had uncomplicated bronchitis (CI=17.26,8). Correlation between the CI in cows and pneumonia in their offspring (rs = 0.568, p 0.001) was found. The content of the MMP in blood of pregnant cows can serve as a predictor of pneumonia in newborn calves (AUC=0.782, sensitivity 85.71%, specificity 81.82%, critical value 0.547 units). The diagnostic value of the CI predictor is rated as very good (AUC=0.812); sensitivity 71.43%, specificity 86.36%, critical value 22.5. The concentration of SMP in the blood of cows and CI in the period of gestation allows us to predict the development of bronchopulmonary pathology in their offspring with high accuracy.
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