Abstract
Objective. To study the lipid peroxidation processes and endogenous intoxication indicators in patients with widespread peritonitis before surgery and during the treatment.
 Materials and methods. The study included 97 patients (43 men and 54 women) aged from 17 to 69 years with purulent peritonitis. According to treatment scheme, patients were divided into two groups. Patients in group 1 received standard treatment, and in patients in group 2 standard treatment was supplemented by immunoreactions. The concentration of diene conjugates and malonic dialdehyde, reduced glutathione, catalase activity and the concentration of medium molecular weight peptides were determined in the blood of patients and almost healthy people.
 Results. The concentration of diene conjugates, malonic dialdehyde and medium molecular weight peptides in the blood of patients with advanced peritonitis increased significantly depending on the clinical stage of the disease, while the activity of the enzyme catalase and the concentration of reduced glutathione were decreased.
 Conclusions. Immunoreactions in combination with standard treatment leads to normalization of lipid peroxidation and reduction of endogenous intoxication on the 5th and 10th days of treatment.
Highlights
Statistical analysis was performed using "Exell–97" ("Microsoft office"). In it was shown, that concentration of biochemical markers of endogenous intoxication and the LP process – diene conjugates (DC), MDA and MMWP – are increasing, while the catalase activity, while the level of the reduced glutathione (GSH) are decreasing with the illness severity enhancement. In accordance with these shifts, the blood concentration levels of DC and MDA were statistically elevated in patients of the first group compared to control group – by 53.7%% and by 56.3%, respectively, and by 49.3% and by 67.0% – in the second group, respectively
GSH were studied as an important indicators of antioxidant system (AOS)
According to the study results, the catalase activity was significantly lower in patients with reactive phase of the disease
Summary
In the study 97 patients (54 women and 43 men) aged 17 – 69 yrs old with diffuse peritonitis of different etiology were included. All of them were examined and treated at the Department of Surgical Diseases No 3 of Medical University of Azerbaijan during 2012 – 2015 yrs. Reactive stage of peritonitis was diagnosed in 16 patients; a toxic one –in 72 and terminal – in 9. The diagnosis was confirmed by the patient’s history data, results of clinical, radiological and laboratory examinations. All 97 patients studied were divided into two groups. In the 1st group 52 patients were included, who received basic therapy, while into the 2nd group – 45, who received antioxidant therapy in addition to basic treatment
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
