Endogenous gastrin stimulates regeneration of remnant pancreas after partial pancreatectomy.

Abstract

The purpose of this study was to evaluate the effect of endogenous gastrin on pancreatic regeneration after a partial pancreatectomy in the rat. Sixty rats were divided into 6 groups. Groups I and II received sham operation (splenectomy only), and groups III, IV, V, and VI received both 66% partial pancreatectomy (PPx) and splenectomy. Endogenous hypergastrinemia was induced in groups II, IV, and VI by gavage of Lansoprozole (LSP) for three weeks. In groups V and VI, gastrin receptor blocker, L365,260, was given continuously using an osmotic minipump. Following three weeks of treatment, PPx alone increased the pancreatic weight and protein content, but not RNA or DNA content (Group III). In the PPx groups, the pancreatic weight, and contents of protein, RNA, and DNA were significantly increased in the LSP treated rats (Group IV). This effect was abolished by L365,260 (Group VI). This results suggest that endogenous gastrin specifically stimulates regeneration of the remnant pancreas after partial pancreatectomy in rat. Induction of endogenous hypergastrinemia may be useful in patients following pancreatic resection for the prevention and treatment of pancreatic insufficiency.