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Abstract
Using a rapid, simple and sensitive radioreceptor assay, a Ca 2+-dependent K +-evoked release of endogenous GABA was demonstrated from rat cortical and hippocampal slices in vitro. This evoked-release of endogenous GABA was similar to tha of [ 3H]GABA release (in its Ca 2+ dependency) but differed from the latter in having a higher signal to noise level. Neither 5-HT nor a stable enkephalin analogue had any effect on endogenous GABA release from hippocampus slices.
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