ENDOGENOUS ANTIOXIDANTS IN SUBCORTICAL VASCULAR DEMENTIA AND ALZHEIMER’S DEMENTIA

Abstract

Low levels of endogenous antioxidant, such as uric acid, have been known to correlate with the risk of neurodegenerative disease. In contrast, high levels of uric acid have been reported the association of vascular events. We hypothesized that there are different patterns of endogenous antioxidant between subcortical vascular dementia and Alzheimer's disease. This study included 74 consecutive patients with probable Alzheimer's disease patients, 12 of subcortical vascular dementia, and 61 of age, sex-matched healthy subjects. Exclusion criteria included end organ failure, including, malignancy, gout, renal, and hepatic dysfunction, and other neurodegenerative disease. Laboratory test included serum uric acid, albumin, total bilirubin, and r-GT. Serum uric acid and albumin are decreased in Alzheimer's disease patients. In contrast, serum uric acid is increased in subcortical vascular dementia. We found that serum uric acid has the different influence to Alzheimer's dementia and subcortical vascular dementia.