Abstract
Simultaneous studies of the release of antidiuretic hormone (vasopressin, ADH) and corticotrophin (ACTH) were performed in unanesthetized trained dogs. Antidiuresis was used as the index of ADH liberation and plasma free 17-hydroxy-corticosteroid levels were used to indicate ACTH release. No correlation was observed between discharge of ACTH and release or inhibition of the release of ADH. Further studies with highly purified vasopressin showed that exogenous ADH was unable to stimulate the secretion of ACTH until a threshold of 3–7 ×103 times the dose reproducing maximal physiologic antidiuresis was exceeded. The physiological significance of the data evidencing ACTH release upon injection of vasopression is debated and questioned.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
