Abstract
By using Gas Chromatography-Mass Spectrometry high concentrations of endogenous γ-hydroxybutyric acid (GHB) have been demonstrated in the rat and mouse gastrointestinal tract, including stomach, small intestine and colon–rectum. GHB concentrations were many folds higher than those present in the brain. High GHB concentrations have been also found in the human operatory specimen of sigmoid colon. Since GHB administration has been found to modify gastrointestinal motility via GABAB receptors, the present results suggest that endogenous GHB might be involved in the GABAB receptor-mediated control of gastrointestinal function.
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