Abstract
Neurons use a calcium-dependent mechanism to optimize the rate at which synaptic vesicles are recycled.
Highlights
It is tempting to hypothesize that the release of the vesicles and their recycling are initiated or controlled by common signalling mechanisms
Armbruster and co-workers—who are at Cornell University and Yale University—have reconciled these results by carefully examining how the rate of endocytosis varies as a function of the number of action potentials delivered at a given frequency, referred to as a burst
Armbruster et al note that this previous study compared the ensemble average rate between boutons, and may have been less sensitive than their own study, which examined the rate of endocytosis within a bouton following differing numbers of action potentials
Summary
Image The rate of vesicle recycling via endocytosis varies with the number of action potentials In eLife, Tim Ryan, Pietro De Camilli, and co-workers— including Moritz Armbruster as first author— report that calcium entry during bursts of action potentials has an important role in optimizing the rate of endocytosis (Armbruster et al, 2013).
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