Endocrinology of the pregnant Djungarian hamster Phodopus campbelli.

Abstract

Factors regulating maternal serum progesterone concentrations during pregnancy in the Djungarian hamster Phodopus campbelli were investigated through changes in (1) concentrations of progesterone and oestradiol in the serum and extracted corpus luteum, non-luteal ovary, and placenta during late pregnancy, (2) prolactin concentrations in the serum, and (3) mass of the fetus, placenta, corpus luteum and non-luteal ovary. Early pregnancy (days 1-4) was characterized by surges of prolactin, corpus luteum growth and increased corpus luteum activity as indicated by increases in luteal mass, progesterone content and serum progesterone concentration. During mid-pregnancy (days 8-11) there was a loss of prolactin surges and a halt in the growth of the corpus luteum, as indicated by stable luteal mass, progesterone content and serum progesterone concentrations that were comparable with those of day 4 of pregnancy. At the same time, the non-luteal ovary began to secrete oestradiol and, on day 12, preovulatory follicles of unknown function were found. During late pregnancy (days 14-17), the prolactin surge pattern was re-established, the non-luteal ovary and corpus luteum contained oestradiol, luteal cell growth caused an increase in corpus luteum size and mass, and serum progesterone concentrations doubled. As late-term pregnancies failed to survive bilateral ovariectomy and the placenta contained little extractable progesterone, it appears that the progesterone of Djungarian hamster pregnancy is synthesized by the corpus luteum throughout gestation.