Abstract
There is great interest in modulating systems for the delivery of drugs, hormones, and peptides. For an endocrine/reproductive pulsatile delivery system, the concept of simulating the normal pulsatile release of hormones in order to enhance fertility began nearly 20 years ago. The actual development of this as a therapeutic has taken place over the past 10 years resulting in the new therapeutic, LUTREPULSE (gonadorelin acetate for injection). LUTREPULSE has been studied for conditions associated with absent or deficient GnRH production by the hypothalamus. The pulsatile delivery of this therapy relies on a mechanical pump at the present time. New developments in the area of drug delivery such as iontophoresis, sonophoresis, osmotic pumps, magnetically regulated drug release, and temperature-regulated drug release may lead to potentially simpler devices for consumer use.
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