Endocrine therapy for hormone receptor-positive advanced metastatic breast cancer

Abstract

For the patients with advanced metastatic breast cancer, clinical treatment aims to relieve the symptoms, improve quality of life and prolong patients' survival. Endocrine therapy has mild adverse reactions and good efficacy, regarded as the first choice of hormone receptor-positive advanced breast cancer patients without visceral crisis. Endocrine therapy may eventually lead to drug resistance. How to postpone the drug resistance, put off the chemotherapy and reduce the pain is currently the hotspot of clinical research. In this paper, we summarized the latest research advancement in endocrine therapy and its combination with small molecule targeted drugs for pre- and post-menopausal hormone receptor-positive advanced metastatic breast cancer, in order to provide a reference for breast surgeons. Key words: Breast neoplasms; Neoplasm metastasis; Estrogen receptor modulators