Abstract
Researchers at Universite Paris Descartes and other centers in Paris, France performed a retrospective, study of 176 patients (93 boys) aged 6 years (range 0.2-18 years) with hypothalamic-pituitary lesions to determine whether the time to diagnosis could be shortened by analyses of clinical and endocrine presenting symptoms.
Highlights
Researchers at Universite Paris Descartes and other centers in Paris, France performed a retrospective, study of 176 patients (93 boys) aged 6 years with hypothalamic-pituitary lesions to determine whether the time to diagnosis could be shortened by analyses of clinical and endocrine presenting symptoms
Among this subgroup of patients with neuro-ophthalmic presenting symptoms, endocrine symptoms were present before onset of presenting symptoms in two-thirds of cases
The French guidelines for the management of obese children state that endocrine or brain tumor should be suspected in case of poor growth velocity with obesity, and the AAP recommendations state that an exogenous cause of obesity can lead to poor linear growth
Summary
Researchers at Universite Paris Descartes and other centers in Paris, France performed a retrospective, study of 176 patients (93 boys) aged 6 years (range 0.2-18 years) with hypothalamic-pituitary lesions to determine whether the time to diagnosis could be shortened by analyses of clinical and endocrine presenting symptoms. The lesions were craniopharyngioma in 56, optic pathway glioma (n=54), supracellar arachnoid cyst (25), hamartoma (22), germ cell tumor (12), and hypothalamic-pituitary astrocytoma (7). In 122 patients presenting with neuroophthalmic symptoms, the mean interval from symptom to diagnosis was 0.5 year, 66% of patients had abnormal body mass index or growth velocity, which preceded the presenting symptom onset by 1.9 years (P
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