ENDOCRINE PROFILE OF THE MALE POPULATION IN RUSSIA DEPENDING ON THE GEOGRAPHIC LATITUDE OF OCCUPATION

Abstract

The goal of research is to examine the characteristics of the hormones of the pituitary-gonadal and pituitary-thyroid gland systems in the peripheral blood of the male population living in different areas of Russia, taking into account the population groups. The study involved 136 men aged 22 to 50 years old, who are permanently resident in the North no less than three generations. Among them there are 80 local residents of Arkhangelsk (64° 32' N), 19 local residents of Vologda (59° 13' N) and 37 local residents of Nes, Nenets Autonomous Okrug (66° 36' N). According to the basis of nationality group of men living in Nes was divided into: Russian - 23 people and settled aboriginal population (Nenets, Komi) - 14 people. We have shown that functional activity of the pituitary-thyroid axis (thyrotropin, thyroxine, free triiodothyronine) in the male Caucasoid and settled aboriginal population of the polar region exceeds its level in the inhabitants of the circumpolar area (Arkhangelsk). At the same time, men living in the mid-latitude area (Vologda) had minimal activity of the pituitary-thyroid axis (triiodothyronine, free thyroxine), compared with polar and circumpolar areas. It was shown that the functional activity of the pituitary-gonadal axis in men living in Vologda (luteinizing hormone, follicle-stimulating hormone, inhibin B, free testosterone, dehydroepiandrosterone sulfate) and in Nes (follicle-stimulating hormone, inhibin B, testosterone, free testosterone, sex-hormone-binding globuline) was higher compared with the inhabitants of the city of Arkhangelsk. The levels of sperm antibodies were minimal in men living in Nes. At the same time, changing the traditional way of life from nomadic to a settled one leads to the negative tendencies such as the decrease of the synthesis reserves of steroid hormones in the settled aboriginal population that is shown by the decreased serum levels of progesterone and dehydroepiandrosterone sulfate.